Wear off? Meaning you won’t feel so awake and maybe hyped up? Or, when might you start feeling withdrawal? If you have caffeine every day that will make yourtolerance much higher, so once you get down to your normal level of caffeine in your body you will feel it has worn off. So if 4 hours is the correct half life, I am not sure if itis, and you drank twice as much cafeine as you usually do, you will feel normal, normal for you in about 4 hours. If you usually don’t drink caffeine at all, it will take longer. If you are asking when the headache might start, and maybe you will feel crappy, almost under the weather, that usually takes around 15+ hours. Unless you have more caffeine before you ever get to the point of any withdrawal.