Here is the data on Renavive
Phyllanthus niruri after extracorporeal shock wave lithotripsy may increase stone clearance for lower pole stones (level 2 [mid-level] evidence)
based on subgroup analysis of randomized trial
P. niruri is plant used in Brazilian folk medicine for urolithiasis
150 patients with renal calcium oxalate stones up to 25 mm received 1–3 extracorporeal shock wave lithotripsy sessions and then randomized to P. niruri extract (Uriston) 2 g once daily for at least 3 months vs. no extract
both groups allowed to use ketoprofen as needed and asked to drink at least 2 L of water daily
among 56 patients with lower caliceal stones, stone-free rate 93.7% in treatment group and 70.8% in control group at 180 days (p = 0.01)
comparing P. niruri extract vs. control for stone-free rates
54% vs. 19% at 30 days (p = 0.02, NNT 3)
69% vs. 35% at 60 days (p = 0.03, NNT 3)
74% vs. 64% at 90 days (not significant)
93.5% vs. 83.3% at 180 days (not significant)
comparing P. niruri extract vs. control for stone-free rates at 180 days
89% vs. 86% for 23 upper caliceal stones (not significant)
87.5% vs. 80% for 26 middle caliceal stones (not significant)
90.6% vs. 62.5% for 56 lower caliceal stones (p = 0.03, NNT 4)
86% vs. 83% for 45 pelvis stones (not significant)
no significant differences in stone-free rates for upper caliceal stones, middle caliceal stone, or pelvic stones at 180 days
Reference – J Urol 2006 Sep;176(3):1020