My grandfather took Oxycodone for a few months and I thought the side effects were terrible. He had no pain at all and really liked it for a few days, but he lost his short term memory to the point that he started to panic one day at the grocery store because he “woke up” there and had no idea how he ended up in the store.
Eventually, he started getting aphasia. He would speak gibberish and expect us to understand him. Finally he started acting like a stroke victim. Half of his body would just go limp. His other half would make these odd random jerky movements.
My grandmother finally took him to the ER and less than 24 hours off the oxycodone he was back to normal as if it never happened. He ended up on high doses of Morphine and was in much better neurological shape.
While I know his reaction was extreme, it made me think really hard about what that drug is doing to people neurologically.
Antinflamatories gave him renal failure and eroded his joints.