On a day to day basis sure humans are capable of significant devastation. And over time it seems our destructiveness is beyond the bounds of nature to correct by itself at least with life, as we’re accustomed to, continuing.
For natural disasters, heavily nuking one of the top world cities or unleashing a manmade plague is about the only way we can compare in terms of scale within an even remotely similar timeframe with things like tsunamis, hurricanes, plagues, city-centered earthquakes and the like. Also keep in mind it’s our ability to create, develop, and adapt that keeps those things from being worse than they are. (Though you could argue, for example, our coastal development that makes a tsunami so devastating in the first place. But that’s getting a little apples/oranges/whatiffy.)
For one shot events, not even close – particularly if you talk about massive asteroids colliding with the planet, supervolcano eruptions (though a nuclear winter might be on par with this), the sun swallowing (or at least incinerating) the earth in a few billion years.
On the other hand there’s something to be said for choosing destruction. Our actions may not be as fast acting or as destructive individually but we elect to take them and I think that counts for something.