Knowing nothing other than they are fictional and are from different historical eras, I can make a pretty good guess that they were the creations of different authors. Yep. That’s the difference.
But I bet that’s not what you were looking for. Perhaps you could be a little more specific. What kind of difference are you looking for? Character? Behavior? Plot lines? Looks? Clothing? Skin color? There are an infinite number of ways to compare fictional individuals. You’re going to have to narrow it down a bit if you want anything useful.