It’s looking to me like the conflict between religion and science will be a theme what with the power struggle between the Catholic clergy and the doctors. And then there’s always the classic of theme of undermining the assumptions about the stability patients relative to their keepers.
I haven’t the foggiest how all the presumably supernatural/extraterrestrial bits come together let alone how a 1960’s serial killer seems to be terrorizing modern day legend trippers, but I’m enjoying the ride and expect it will come together. Plus the journalist reminds me of Ellie Bly. That’s never a bad thing.