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How do long term stress and drugs age the face?

I saw my ex recently and I know many people his age but I’ve not seen any men with such deep lines in their face and bags / lines under their eyes. A female relative of mine, 49, has smoked a lot of crack and drinks beer almost daily and she just looks “rough.” It’s hard to explain; but the softness in her face is gone. She looks like how I’d think a heavy drinker would look who gets into fights. How do stress and drugs change the smoothness of the face?

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