How do you mean?
Do you want to share photos on the web, like Flickr?
Or do you want to upload to a print facility, like Snapfish?
Or do you want to have rigid controls as to identifying folks you know who will be allowed to see your pics, like Facebook?
(And yah, I know, there’s a lot of similar functionality shared across all three of my examples.)
Maybe you could explain what you’ve tried before and why it didn’t work for you?
Oh yah, all of those sites have zero-download HTML forms to handle uploads from your PC. Those are simplistic, requiring that you choose just one photo at a time. Or you can alternatively auto-install each site’s plugin to your browser to make multi-uploads easier/faster.