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Should you donate to charities that are on the US stock exchange?

I donate to local soup kitchens and Goodwill; sometimes animal right’s groups. A lot of people donate to companies that are on the stock exchange such as St Jude’s Hospital.
Do you think your donation to St Jude’s would be useful for them or do they regularly have organizations donating hundreds of thousands of dollars per year ? I know all their tv advertising costs a small fortune. I love St Jude’s , the late Danny Thomas and Marlo Thomas. But would my $20 be needed?

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