I follow just under 300 people so it’s kinda hard to pick a favorite…
Michael Arrington from TechCrunch is pretty informative. Most of his posts have links to the new articles on TechCrunch.
Corvida is a cool person to follow. She has her own tech blog and tweets about cool new sites and gadgets.
Most of the people I follow are web designers and technophiles, so if you are interested, you can go through my follow list here.
If you’re looking for cool people to follow try this wiki and Twellow.