What @jerv said.
Also, most federal power to regulate state affairs comes from the current expansive jurisprudence surrounding the U.S. Constitution’s commerce clause, which may or may not violate the spirit of the clause (I personally don’t think it violates the letter of the law here). In at least one case, SCOTUS decided any impact on the market impacts interstate commerce, even if the transaction took place entirely within a state.
But there are lots of broad powers granted to the feds anyway: transportation, patents/copyright, money (I’m hesitant to say monetary policy), defense, foreign relations, etc.