Yes, absolutely. Back in the mid-60s my grandmother had a beautiful long-hair calico with brilliant colors. He was said to be a boy. We never had a chance to cash him in for the ten million dollars because he was run over by a car.
His name was Ponchita.
Later in life I found a stray gray cat with differing shades of gray. I kept her, called her Mathilda and when she had a litter of kittens (5), two of them were calico (female), so I kept them.
Soon all three had litters in the spring, a week apart. all kittens were either solid white, solid orange or tiger striped greys with one beautiful long-hair calico female.
I tried in vain for years to let them breed a calico male, but no luck.