Yes, I have pretty much accepted it as a fact of life since none of my medications do anything worse to me than the disease they control does.
The hardest for me to accept was when I was 17 and my IBD got severe enough to require me to go on the medication that was pretty much the end of the line in terms of medical technology for treating IBD (barring surgery). While usually the most effective medication, most people try to avoid needing it because it harms your immune system, has to be received intravenously at the hospital every 6 weeks, and has lots of possible side effects.
The worst thing about going on this medication for me was that it felt like a huge commitment. Because the medication was based on mouse proteins, people were frequently mildly allergic to it, and in fact you have to take Benedryl at the hospital before your infusion every time. Because of this, you cannot “take a break” from this medication. If you do, your body will build up antibodies to it and you become allergic to it and can never use it again.
I was terrified because I knew A.) this was the last medical option before surgery, so I was pretty stuck with it B.) if it worked for me, awesome, I’d stay on it for the foreseeable future, but my life would be limited in lots of new ways. Making the commitment to be able to access a hospital at least every 6 weeks meant that I wouldn’t be entertaining any notions of doing a study abroad in college. The medication is untested during pregnancy, so if I were still on it later in life and wanted to have kids, I’d have to make the decision to either stop the medication and never be able to go back on it again, or take a chance with my pregnancy, or just forego having kids. The whole thing was very frightening and made me feel like my independence had become far more limited.
Luckily, or unluckily, that medication stopped being effective on me after 2 years on it, so I was never faced with any difficult decisions. I stopped it and got surgery. Now all my medications come in pill form which is much easier to swallow (pun totally intended).