Update: We only had time for a day trip and got really lost. We did Biodome, Botanical Gardens, and dinner in Little Italy (the friend I went with is Italian).
I thought the Biodome was not that great.—it wasn’t anything special compared to other places I had been, and I wish we had gone to the Biosphere instead (we got them kind of confused). The gardens were nice but also the one where I live (SF) is free. The gardens were cool I recommend making a day of it with a picnic. We got kind of rushed because I got really hungry and grouchy so bring food! It’s quite large.
Little Italy was fun, and there is a big open air market that was very sweet looking. We also drove along a street that looked like a great place to spend the day eating and shopping it was called St. Denis.
Bring a good map if you go there. We got lost for HOURS and several people I talked to said they got lost too! Be careful with all of the turns on the south side of the Champlain Bridge.