I was not going to chime in here, because I am not nearly as up on the history as a lot of other Flutherers, who I thought would have given you a response by now. From the NY Times:
“In early 2006, Ben Finkel and Andrew McClain, friends from Brown University, started http://Fluther.com, an online knowledge-sharing collective, when both were living in San Francisco. ”
Per this thread, the first question was “What’s so special about salt and pepper?” asked by Ben.