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What type of pain makes you dangerous to be around people?

What type of pain makes you so miserable that you might lose it and go Neanderthal on someone, for example, if you had a tooth ache no one better come near you, or an ear ache, back ache, hurting feet, or maybe neck pain, etc.? And when I say pain, I mean like level 8 or above pain, the throbbing, stabbing, crippling kind that hardly responses to painkillers.

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