Derived from the ancient comedians: Holy schtick Batman this is such fun.
http://www.etymonline.com/index.php?term=holy
Holy has been used as an intensifying word from 1837; in expletives since 1880s (such as holy smoke, 1883, holy mackerel, 1876, holy cow, 1914, holy moly etc.), most of them euphemisms for holy Christ or holy Moses. Holy Ghost was in Old English (in Middle English often written as one word).
http://www.etymonline.com/index.php?term=holism&allowed_in_frame=0
holism (n.) Look up holism at Dictionary.com
1926, apparently coined by South African Gen. J.C. Smuts (1870–1950) in his book “Holism and Evolution” which treats of evolution as a process of unification of separate parts; from Greek holos “whole” (see safe (adj.)) + -ism.
This character of “wholeness” meets us everywhere and points to something fundamental in the universe. Holism (from [holos] = whole) is the term here coined for this fundamental factor operative towards the creation of wholes in the universe. [Smuts, “Holism and Evolution,” p.86]