Unless he gets help, and you are actively involved with that, including going to at least one therapist visit with him (as a couple and helpmate), this will continue, and probably get worse if you stay with him.
He already suffers frim depression, and doesn’t seem to be being helped by the medication (if he’s taking it), and he most likely also needs to be seeing a therapist, which I gather he isn’t. And his psychiatrist or primary care doctor may need to change his medication, or change the doseage.
He’s already shown a tendency to push you away when things get rough for him. That’s not likely to change.
If I were you, I would want to get in contact with his immediate family, to see if they are aware of this situation, and if they are doing anything to help him.
In the meantime, if he’s not talking to you, I would write up a note to ask him to accompany you to a doctor appt, to get him some help.
If he either doesn’t answer you, or doesn’t agree to get help, I would urge you to move on with your life without him, and not sit around hoping for him to come back, or change. He might come back, but without getting help, this situation will continue.
So sorry this is happening to you. Best of luck.