I am a web programmer/developer. Before that, I spent a few years in college student affairs administration (long story). I like webdev a lot, but if I had to do it over...
I started college back when dinosaurs ruled the earth (where, by "dinosaurs" I mean members of Ronald Reagan's administration). Knowing what I know now (both about my interests and aptitudes and how technology has progressed) I would have double majored in movie production and computer science. Maybe I'd have hooked up with Pixar back in the early days and been a gazillionaire by now. Ah, sweet hindsight...
Seriously, I am happy with my career. I've had a lot of great experiences over the years. I haven't made my fortune (yet), but I'm like where I am.