Yes, in addition to what @kritiper wrote about where the camera is, the lenses cameras use are not the same as a pair of human eyes, and there are different kinds of lenses, and with digital cameras there’s a computer processing the light and modifying it. The sensitivity to light levels, light/dark contrast, and colors is different. Lighting can also makes big differences.
Another huge difference between pictures and seeing someone in real life is that a photo is still and 2D, and actual humans move all the time and are 3D. Many instants, when frozen in a photo, look rather weird and unlike what a person seems like when watched in person.
Also, different humans see differently, with different types of color blindness and with different viewing defects. Many people have vision defects they are not aware of, because they are used to their own vision and changes tend to be gradual.
You can test these things for yourself by comparing what people look like in real life to photos of them.
However, attention and mental expectations also play a role. Many people are used to looking at themselves, and to relating to looking at people and comparing them to ideas. For example, this is how you can have people who are starving themselves but think they look fat and overweight.