I wouldn’t say safe, but I would do it if it was the best option and I needed to travel. From what I have read very few cases are coming from airports and air travel. I know people who have been flying a lot over the past 6 months.
I’d wear a KN95, bring some hand sanitizer, and just do it.
I would avoid Thanksgiving Wed, Thur, and Sunday and December 18 thru Jan 3 if possible.
Driving you still have to deal with gas pumps, public bathrooms, everything has a little something.
Edit: I just saw you said March, I think that’s good to wait several weeks past Christmas, but remember March starts up spring breaks, so if it were me I’d try to travel early in March assuming cases are coming back down again. I expect a spike from the holidays. I hope I’m wrong.