@mcbealer… hmmm.
Usually, us home users connect our computers to a (wi-fi) router of some sort. That router’s IP address is what OpenDNS sees in terms of applying the settings you prefer.
Since OpenDNS doesn’t actually see your PC directly, I don’t think you’ll be able to configure it on a per-machine basis.
You’d need to ensure each computer has a unique IP when connecting directly to the internet. That’s not something home users typically get. Actually, there’s almost no organization (home, business, corporation) that connects all of their PCs directly… in part due to the fact that IPv4 doesn’t offer enough unique addresses to support it.