Second Cirque’s shows-haven’t seen Zumanity, but heard that it is pretty sensual.
My vote for sophistication and production values go to “O” and “Ka” which are technically and artistically astounding. Worth the price of admission in both cases.
As for other night life, anything on Industrial Parkway should suffice (if you’re into that kind of thing). Some of the night clubs at the resorts are pretty cool too (haven’t been to many of them). The Palms’ nightlife clubs (Playboy, Ghostbar, Rain), are pretty trendy and cool; Hard Rock Cafe is a more casual hangout too.
Forgot to mention that when I was researching entertainment in Vegas awhile back, I came across a cool website and forum/blog that was pretty useful for everything from shows, to dining, to entertainment and hotels…still use it too:
http://www.everythinglv.com/
They may have more info on the clubs and shows you’re researching.