Cybernetics. We have been seriously co-evolving with machines for about 600 years now. I think the next big evolutionary breakthroughs will be in the area of human-machine interfaces; i.e., machine-assisted intelligence and collective decision-making. The Borg come to mind, only I think that in our version individuals will not be so subordinate to the collective, and human-hive intelligence will not be so centralized and directive.
I think machine assisted individuals will develop the personal bandwidth necessary to manage problems posed to a collective intelligence (of the sort described by James Surowiecki in “The Wisdom of Crowds”). It could be something like Fluther, only the membership would be more organically constituted, dialogue would be more serious and substantive, and the output would constitute the state of knowledge in any given field at any moment—and that knowledge would be applied in real-world situations.
This would necessarily entail that we evolve institutions, structures and processes for accrediting individuals, ideas and methods on the fly.