I like the content of John Gruber’s Daring Fireball… but think the design is ass.
(It’s exactly what he likes though… so good for him. But it’s simply too monotonous and when you’re scanning through to look for some gem you recalled seeing earlier, it can be really hard to find.)
I do like the design and layout of Google Reader. Not a site itself, per sé... but it’s a great utility for consolidating and managing the content of lots of sites together.