We have 5 dogs ranging in weight from 35 pounds to 130 pounds.
No problems as long as all dogs remember I am alpha (and that I have the squirt bottle as well as the control of all food, treats, who gets to sleep on the couch, and opening the back door.) They have learned that when I say “no,” “leave it,” or “down,” that is what they have to do or else they will be squirted or put out in the yard by themselves until I am good and ready to let them in. In contrast, they also know the words “Good dog!,” commands such as “sit,” “stay” and “up,” and the phrase “Time to feed the dogs!”
In other words, I am the source of all that is good, and if they want it they need to do what I say.
I do have one fairly aggressive dog who tries to steal from the females or express dominance over one particular female when he thinks I am not around. I do my best to make him think I am always around and even if I am not, I will be and I will squirt him.
Note: all our dogs are neutered or it would be much harder to control the most aggressive male.