Shilolo, I became very intrigued with this because you stated there was nothing credible about the trials. Now, I am totally confused. I went to the same link you provided and on page 6 there is a section called Clinical Observations, that actually lists methods used during the clinical trials: “Kupperman Menopause Index, gynecological check-up’s, psychological evaluations, Spielberger-Hanin Anxiety Inventory, electrocardiography, ultrascanning of the uterus and uterine appendages and lab analyses of blood and urine samples.” Sounds pretty thorough to me!!! So, I don’t know how you concluded that it was based on questionnaires only… I actually read the whole thing and it’s very convincing (the parts I could understand, haha!), including the results they got from animal studies. Pretty fascinating… Shilolo, you should read some stuff women are posting online – a lot of incredible individual experiences. I got most of my questions answered. Oh, also, on Amberen’s website they state that it’s “against their policy” to bill your credit card without your knowledge. That’s important to me, too, because I actually had to close the card once, because I couldn’t get rid of some nuisance charges! Good luck!