That really does depend on what you need. If you could post a list of features you’d want then it’d be much easier to recommend you one (e.g. Bloglines, Netvibes, etc.).
I just read on lifehacker and article comparing Google Reader with Netvibes. Interesting article for sure, and it seems you have lots of advantage using a desktop reader. And certainly some using the online one. Gonna try Netvibes. Gonna check out Bloglines as well. Thanks for your answers!
i use google reader. there’re lot’s of greasemonkey userscripts that you can tweak the interface to the way you like. it’s the most versatile one. (but you’ll have to use firefox browser.)