No more extended family, distance from food production (no one has chickens or raises a pig each year, or plants a family garden) you are no longer assured that your children will do better economically than you did, people don’t play as much music in the home any more (every home used to have a small piano or organ) The “Bowling Alone” syndrome has affected neighborhoods so the social structure of towns has broken down, CEO’s used to get paid 40 times what the workers earned, now it’s more than 500 times, people don’t know how to shoe a horse or milk a cow, it’s hard to work on your own car if you don’t have a computer, you can’t call “Information” any more, families don’t seem to enjoy the movies together in the same way they used to, I could go on.
All that being said, we also live in a less racist, more inclusive society now (including gender issues, though things are imperfect) and I think that is healthier.