It depends on the situation a lot.
Gut feelings are usually a pretty good way to go for many situations, though. I often find that when I go against my instincts things seem to go awry. Example: I was planning a weekend trip in spite of my feelings that it wouldn’t go well. I went anyway, and it ended up being one of the most miserable weekends of my life.
But other times you can’t go with your gut instincts, usually when a lot of different people/elements are involved. It takes a lot of thinking to figure out what the right reaction is, even if it’s not what you would do instinctually.
Hope that helps a little bit.