Well, I know quite a few medical professionals in RL and the comment I most frequently hear about House is that it’s the opposite of reality in one critical respect.
One of the main points they stress in Medical training is “When you hear hoofbeats, think horses not Zebras”.
This means that the vast majority of diagnoses are going to be of fairly common diseases. You can’t run every medical test in the book just to rule out every possibility.
Because their education presents them with a vast variety of esoteric diseases and processes, many of which they will never see in their entire carreer.
However, the formula for House is the exact opposite. Every rare syndrome or disease ever in existence pops up like clockwork on this show each and every week.
It’s not as if it’s total BS and they are inventing things that don’t exist. It’s just that all of these EXTREMELY RARE things keep popping up at this one little hospital in the middle of NJ. Now how likely is that?
But that’s the main feature of this character’s skillset. He is the expert diagnostician so it’s sort of unavoidable. Just know that if you watch House long enough, every single rare medical zebra will make it’s way to his door sooner or later.
:D