I don’t think it would bother me if my neighbours had a garage sale every weekend. If they seriously have that much junk lying around their house, it’s fine. It would become an issue if they turned it into a business and purchased/made items just to sell from their driveway, but that has more to do with the fact that they are running a business, not any nuisance to the neighbourhood.
From the garage sales I’ve held and been to, it’s usually busy in the morning, but quite sporadic during the day. I nearly always sleep in on weekends and we have off-street parking, so I wouldn’t mind.