“I See You” by Leona Lewis from Avatar because it’s just an extremely powerful, strangely emotional and insightful song.
“I’ll Stand By You” because it’s a really loving song that my mom used to sing that to me all the time before my parents divorced. I can’t really listen to it anymore.
Of course, there’s “The Circle of Life” from The Lion King. I can’t think of anyone who isn’t empowered by that song.
“I’m Yours” by Jason Mraz just makes me really happy because it’s whimsical and cheerful.
“Speed of Sound” by Coldplay…not really sure why, actually.
The Harry Potter music gets a strong emotional reaction from me, too, but that’s probably just because I’m a Harry Potter freak. :P
“Not Ready to Make Nice” by The Dixie Chicks. I’m not actually a fan of country but I love the message.
There are probably a lot more that I can’t think of off of the top of my head.
That dang Christmas Shoes song gets me every time, too.