Here’s a good list of flutherfolk’s choices to refer to. Scroll down and you’ll find a cumulative list of titles.
@jaytkay‘s suggestions (above) are excellent. Michael Chabon is a very fine and inventive writer with a superb command of the language. I second The Whistling Season, especially for its narrative voice.
The Story of Edgar Sawtelle seems to be a love-it-or-hate-it book. Even if you’re not a dog lover (cat person here), the intimate look at the training of the dogs is fascinating. You may want to refamiliarize yourself with Shakespeare’s Hamlet if it’s not already at the top of your mind when you start this one; the author’s working out of parallels is nothing short of brilliant in several key respects (and a little curious in others). In terms of parallels, however, I found the ending disappointing—disappointing as in I cursed aloud and wanted to throw the book across the room, a gesture that would have been satisfying in principle but would have done some heavy damage to the environment.
Others, of course, loved it.
The author definitely had some good days and some bad days, and my sense of it is that he didn’t use the good days to go back and clean up the rough spots.
I also second @gailcalled‘s recommendation of Jhumpa Lahiri.