For that amount of money I would. Like @Ben_Dover said, the cashier could be held responsible. The few cashier jobs I had stressed the importance of having the right amount of money in the drawer at the end of the shift, and if you were too far off you were reprimanded.
If it was a much smaller amount, I wouldn’t bother.
Once I had to pay late fees at the local library and paid the librarian with a $20 bill. I didn’t look at the change, when I got home I noticed I had more than $20 in fives and ones. I don’t know how the heck she managed to do that, but I went back to return the extra money. That’s the only time I can think of someone gave me too much change back and I didn’t notice right away. They were very happy I’d gone back, but I would have felt awful keeping the library’s money!