Well, just to be a little less hemisphere-centric, in the Northern Hemisphere (and at the mid latitudes), both high- and low-pressure weather systems tend to move from west to east. In the Southern Hemisphere and at mid latitudes, weather systems move from east to west. At the Equator and lower latitudes, there is no prevailing direction of storms, and at the Poles the weather systems generally operate counter to what is seen at lower latitudes in the same hemisphere.
More to the point of the OP’s question, since I-44 (most of the US Interstate Highway system from coast to coast, in fact) follows lowland routes, more or less parallel to rivers, instead of along mountains, hills and ridges. Weather systems also have somewhat more trouble crossing mountains and ridges, so they also run along river valleys, too.