A very hard question to answer! It would be between “Have they invented immortality potion?”, “Have the found the fountain of youth?”, or “Do I look beautiful?”.
Excuse me, would you mind awfully if I asked you to remove your toe from my anus? There’s a good chap, it was beginning to feel rather uncomfortable old bean.
But really, this is not an easy question to answer if your serious about it. So its probably best not to think about it and just live the life you have.