When the reality of life gets in the way. Money troubles, tragic events, opportunities in other locations, illness, all sorts of reasons can put stress on a relationship.
I also agree with what other jellies said here about trust and respect. But, it isn’t what first came to my mind because often people, especially women, feel they love someine and stay in a bad relationship, and really I question if that should be called love or some other term, because the relationship can be so dysfunctional. It can be like Stockholm Syndrome after a while in its extreme.