I usually cry and keep putting one foot in front of the other. I have to say that most places I have lived don’t hold a tremendous amount of sentimental value, it usually has more to do with me truly enjoying living there and being sad about leaving those things.
What you need to do is find what to be happy about in the new place and focus on that. If you have an exercise routine, find in the new place the gyms you will go to and have that ready. Research the tourist attractions and get exciting about visiting the new things to see and experience. If you have always wanted to take golf lessons, do it. Those types of things help the transition go faster. If you move to a place that you associate with vacation you will be on vacation all the time. That’s how I felt when I moved to FL after college, and every time I have moved back to the state. For you it might be big city or mountains or countryside. Where you live can make an incredible difference in your life.
New chapter in the book, go for it. If your town has bad feelings mixed in with good, then when you leave there will be a huge weight lifted. But, maybe you don’t have bad memories just lack of job opportunity? You didn’t say why you might move.
You can always go back home. Leaving doesn’t mean you can never go back to visit or live. I know many people who have lived in the same city more than once.