Yes and no.
Entirely depends on the individual.
Just last night I was at a French restaurant. Our server and bartender was a older and slight woman. She had natural breasts that even with a bra obviously hung very low. Her choice of tight and low cut top said that she had no hang ups about their state. Yes please.
On the other hand bolt ons can be hot too to me, though not as easily. The best example is wealthy wives that are cute and unintentionally charming. Their slightly awkward bosom gift contrasting with their sweet demureness. Hotter than hell.
Ginormous bags on bimbos are for me not much more than a curiosity.
For me, if we are talking largeness, natural is much more interesting to me.
Then again, women with practically no tits at all are also sexxy as heck.