Yes, it will jump out at people. They will wonder “why” you’re depressed (like there’s one event out there), and look for answers in the little piece of your life they know about.
I had a manager who I quit a job with, I had given my real reason for leaving on a form and she brought it back with some advice not to share so much when you’re dumping a group of people. She was pretty smart.
It sounds callous, but it seems the world at large thinks there’s only one acceptable reason to leave a job; “other opportunities”. So I’d simply use that if you need to give a reason.
You can define those opportunities for friends, or those you care for, but for the employer as a whole, there’s usually no need to go any deeper.