There were extensive trade routes in North, Central and South America in Pre-Columbian times and these included North/South routes from Central America to the Southwest. There are several examples of Southwestern Turquoise in Aztec areas and evidence of Parrot feathers among the Hopi/Pueblo/Zuni tribes. Although, there has been recent work showing that much of what they had assumed was Southwestern turquoise was actually from a local source.
Many of the explorers of the time of western expansion followed existing native American trade routes across the country. It was not by chance that they found the shallow river crossing points and passes through the mountaln ranges. I also seem to recall reading at one time that the major route used by the Spaniards to enter Texas and Louisiana and beyond, El Camino Real (the Royal road), followed old trading routes between the Aztecan empire and that of the Mound building cultures, such as the Hopewell who occupied much of the Mississippi River regions upward into the Great Lakes.
Between Central and South America it gets a little more problematic. While there are extensive road networks in the Andes and along the Western Coast and corresponding roadways in Honduras, Belize, Mexico and the other countries of the area the constriction at Panama seems to have kept land travel to a minimal there is still evidence of both trade goods and ideas between the two areas. I would say there was a greater chance that this trade was up and down the coastal towns than any overland commerce.