Does it interfere? It depends upon how bad his cancer was and the treatment he had.
There is a wide range of outcomes.
Let’s say he had his prostate removed. He could still have erections and still have the feeling of orgasm. But he would not be ejaculating any sperm. That has the advantage of no mess, and no chance of pregnancy!
or
He could have had both nerve bundles removed with the prostate and not be able to get an erection in the normal fashion. He might need to use a pump or pills or an injection.
or
He might still have his prostate and is being treated chemically by hormone therapy or cancer drugs, If he is taking drugs to lower his testosterone level to zero he might have no desire or even forget why he thought women were attractive.
or
He could have be treated with radiation which sometimes brings other problems .
or
He could be on active surveillance and worrying about his PSA numbers all the time.
No matter what the treatment, if he still has the desire and can talk, he can participate and both partners can enjoy it.
He won’t be delivering fake porn video squirts but it will still feel good.