Yes.
Actually it can mean lots of things in terms of medical issues & mortality. Several reliable studies show that people suffering from psychiatric disorders die from a wide range of causes, at over 2 times the rate of the general population :
Premature mortality among people with severe mental illness
https://www.sciencedirect.com/science/article/pii/S0920996418301981
Causes of death included cardiovascular disease, respiratory illness, Parkinson’s disease, diabetic complications, and accidents. Basically, severe mental illness can be physically debilitating while at the same time reducing individual capacity for self-care. But suicide is always part of the risk profile.
In Naomi’s case there’s not enough info at this point to assume much. She was 76 though, and actually beat the odds for premature mortality related to clinical depression.